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Bromocriptine (Parlodel)

Bromocriptine (Parlodel)


Bromocriptine is a drug, a stimulant of central and peripheral dopamine receptors D2 (a semisynthetic derivative of ergot alkaloid).


Pharmachologic effect


The drug actively affects the circulation of dopamine and norepinephrine in the central nervous system (CNS), reduces the release of serotonin.

In connection with the stimulating effect on the dopamine receptors of the hypothalamus, bromocriptine has a characteristic inhibitory effect on the secretion of the hormones of the anterior lobe of the pituitary gland, especially prolactin and somatotropin. Endogenous dopamine is a physiological inhibitor of the secretion of these hormones.

Synthesis of prolactin bromocriptine does not violate. The inhibitory effect on hormone secretion is removed by dopamine receptor blockers (eg, chlorpromazine).

Bromocriptine (like apomorphine, also a stimulant of D2 receptors) exerts an emetic effect, reduces body temperature, reduces akinesia caused by reserpine, tetrabenazine, antipsychotic drugs. The drug has an antihypertensive effect, associated with the effect on the central nervous system, affects the sympathetic nerve endings and smooth muscles of the vessels. Reduces the blood levels of catecholamines.

Unlike ergometrine, methylergometrine and other similar ergot preparations, it does not have a "mother" (oxytocic) action. On the contrary, it inhibits uterine contractions caused by metergergometrin.

Uses of Bromocriptine:

  • It is used to treat acromegaly.
  • It is used to treat high prolactin levels.
  • It is used to treat Parkinson's disease.
  • It is used to treat some prolactin-secreting tumors.
  • It may be given to you for other reasons. Talk with the doctor.


What is the dosage for bromocriptine-oral?

Bromocriptine should be taken with meals.

  • The dose for treating hyperprolactinemia is 2.5 to 15 mg daily. The initial dose for treating acromegaly is 1.25 to 2.5 mg at night. The dose may be increased by 1.25 to 2.5 mg every 3 to 7 days up to a maximum dose of 100 mg daily.
  • Parkinson's treatment is started at 1.25 mg every 12 hours. The dose may be increased by 2.5 mg a day every 2 to 4 weeks up to a maximum dose of 100 mg daily.


Hyperprolactinemia-Associated Dysfunctions (Parlodel)

Indicated for treatment of dysfunctions associated with hyperprolactinemia including amenorrhea with or without galactorrhea, infertility or hypogonadism; also indicated in patients with prolactin-secreting adenomas

1.25-2.5 mg PO qDay initially; may increase by 2.5 mg/day q2-7Days until optimal therapeutic response achieved

Usual therapeutic dosage ranges from 2.5-15 mg/day

Up to 30 mg/day has been used in some patients with amenorrhea and/or galactorrhea


Parkinson Disease (Parlodel)

Indicated as adjunctive treatment to levodopa for the signs and symptoms of idiopathic/postencephalitic Parkinson disease

1.25 mg PO q12hr initially; may increase dose by 2.5 mg/day q2-4Weeks until optimal therapeutic response achieved

Safety >100 mg/day not established


Acromegaly (Parlodel)

Indicated for acromegaly

1.25-2.5 mg PO qHS for 3 days initially; may increase by 1.25-2.5 mg/day q3-7Days until optimal therapeutic response achieved

Not to exceed 100 mg/day


Type 2 Diabetes Mellitus (Cycloset)

Quick release formulation (Cycloset) is the only bromocriptine product indicated for diabetes mellitus type 2 as adjunct to diet and exercise to improve glycemic control; there is currently no therapeutically equivalent generic version of Cycloset available in the United States


0.8 mg PO qDay initially; may increase by 0.8-mg increments qWeek as tolerated

Usual dosage ranges between 1.5-4.8 mg PO qDay; not to exceed 4.8 mg (6 tablets)/day

Note: Cycloset is not indicated for hyperprolactinemia, Parkinson disease, or acromegaly

Parlodel (Bromocriptine)  30 tabs 2.5 mg/tab